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Search Results for " sirt1 activator 1 "

9

Compounds

Cat No. Product Name Synonyms Targets
T81154 SIRT1 activator 1 Sirtuin
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp. mangrove fungus, exhibits angiogenic effects in zebrafish and protects human endothelial progenitor cells (hEPCs) from AngI...
T24791 SIRT1-A2 SIRT1-Activator-A2,SIRT1A2,SIRT1 Activator A2
SIRT1-A2 is a SIRT1 activator.
T4062 CAY10602 Sirtuin
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende...
T16932 SRT 2183 Apoptosis , Sirtuin
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T8480 Tenovin-6 Hydrochloride Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
T16342 KL1333 NQO1 activator 1 NADPH , Mitochondrial Metabolism
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ...
T77697 BML-278 BML278,BML 278 Sirtuin , Histone Methyltransferase
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...
T69365 HMS607P03
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP...
T35812 CAY10591 CAY10591
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the...
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